| Emergency Services (National) | 112 (from any cell phone) | Free, connects to nearest emergency control room |
| Ambulance / EMS (Western Cape) | 10177 | Direct medical emergencies |
| South African Police Service (SAPS) | 10111 | National police emergency line |
| Mossel Bay SAPS Station | 044 606 5600 | Local police station |
| Mossel Bay Fire & Rescue | 044 606 5100 | Fire, rescue, hazardous incidents |
| Municipal Control Room (24/7) | 044 606 5000 | Water leaks, electricity faults, municipal emergencies |
| Life Bay View Private Hospital (ER) | 044 606 5103 | 24-hour emergency unit |
| Mossel Bay Provincial Hospital | 044 604 6100 | Public hospital & emergencies |
| NSRI Station 15 (Sea Rescue) | 082 990 5955 | Sea rescue emergencies |
| Traffic Department / Road Incidents | 044 606 5200 | Accidents, road hazards |
| Poison Information Centre | 0861 555 777 | 24-hour advice line |
| Childline SA | 0800 055 555 | Child protection & crisis support |
| Gender-Based Violence Command Centre | 0800 428 428 | GBV emergencies (call or 1207867# free USSD) |
| Suicide Crisis Helpline (SADAG) | 0800 567 567 | 24/7 mental health support |
| SPCA Mossel Bay (Animal Emergencies) | 044 693 0824 | Stray, injured, or abused animals |
| Eskom Fault Reporting | 0860 037 566 | Electricity supply faults |
| George Airport (Emergencies / Security) | 044 876 9310 | Nearest regional airport emergencies |
